报告题目：Recent developments in the enantioconvergent hydrogenation of olefins
报 告 人：Pher G.Andersson 教授
报告时间：5月29日 16:00-18:00
报告地点：思学楼B204
报告人简介：
瑞典斯德哥尔摩大学Pher G.Andersson教授，国际著名的不对称催化氢化专家。在过去20年里致力于发展高效高选择性的不对称催化反应，在不对称催化领域做出了创新性和系统性的研究工作。Pher G. Andersson教授到目前为止，已经发表了203 篇学术文章和多部专著，多数文章发表在国际化学顶级期 刊Chemical Reviews, Chemical Society Reviews, Nature Catalysis, Nature Communications, Journal of the American Chemical Society, Angewandte Chemie International Edition等， 其中在国际化学顶级期刊J. Am. Chem. Soc.发表39篇。Pher G. Andersson教授在不对称催化研究工 作受到了国际同行的广泛关注，并且全部工作的引用次数超过了14000次，h指数为55，近年来文章引用次 数在400-500次/年。由于Pher G. Andersson教授在不对称催化领域的杰出贡献，他获得了AstraZeneca奖 “creativity in organic synthesis” （2004），瑞典Ullaoch Stig Holmquist科学奖（2015）。
报告内容摘要：
Our research group has in the last 20 years mainly been involved in development of catalytic asymmetric reductions of a large number of substrate classes ranging from un-functionalised1 as well as functionalised2 olefins, ketones3 and imines4. The early research was mainly focused on the development of new catalysts and study of new substrates (vinyl fluorides,5 tetrasubstituted olefins6 etc). More recently we have become more interested in studying the specificity of a given catalyst towards the substrate.7 The main goal has been to develop catalysts that specifically reduces one substrate over another and use this feature to develop new reactions and further advance the field of catalytic asymmetric synthesis.
Another interest concerns the development of enantioconvergent hydrogenations. A major drawback of the asymmetric hydrogenation is that it is stereodivergent in regards to the geometry of the olefin. This means that E and Z olefins give rise to opposite enantiomers and requires the olefin to be pure, otherwise mixtures of enantiomers are produced. A convergent hydrogenation would instead convert both E and Z olefins into the same enantiomer, which would allow isomeric mixtures of olefins be used directly.
主办单位：化学化工学院
科学技术发展研究院
